Repanos Costa, Mukherjee P, Alwahab Y
ENT Department, Royal United Bath Hospital, Bath, UK.
J Laryngol Otol. 2009 Aug;123(8):877-9. doi: 10.1017/S0022215108004106. Epub 2008 Dec 4.
Peritonsillar abscess (quinsy) is one of the most common ENT emergencies. A 2002 UK audit of quinsy management revealed that an average ENT department treated 29 cases annually; the most common treatment was needle aspiration with intravenous antibiotics, and culture of the aspirate was often performed routinely. The aims of our study were to evaluate the value of routine culture of quinsy aspirates, and to establish whether the information thus gained was clinically useful.
We examined the notes of patients admitted with quinsy to two hospitals in south-west England, from January 1998 to January 2004 in one hospital and from January 1995 to January 2005 in the other. A total of 577 cases was found. Aspirated pus had been sent for culture in 119 (21 per cent). These cases were examined in more detail.
Of the 119 patients, 78.2 per cent (93/119) were treated with either a cephalosporin or penicillin, plus metronidazole. Streptococcal species were cultured in 43.7 per cent (52/119) and anaerobes in 23.5 per cent (28/119; of these cultures, 5.9 per cent (7/119) were pure anaerobes only). All the anaerobes were sensitive to metronidazole. One of the 119 cultures, growing aerobic bacteria, was resistant to penicillin; however, this patient improved clinically on a combination of penicillin and metronidazole. No patients had their treatment changed because of culture results.
There appears to be no need to routinely culture quinsy aspirates, based upon our findings (of 16 hospital years) and previous studies (which found no recorded episodes of treatment change as a result of culture sensitivities). The combination of penicillin or a cephalosporin, plus metronidazole appeared to be theoretically effective in 99.2 per cent (118/119) of our specimens; this finding is supported by other studies. However, the rare but potentially life-threatening complications of quinsy must be recognised.
扁桃体周围脓肿(咽峡炎)是耳鼻喉科最常见的急症之一。2002年英国对咽峡炎治疗情况的一项审计显示,耳鼻喉科平均每年治疗29例;最常见的治疗方法是穿刺抽脓并静脉使用抗生素,且通常会常规进行抽出物培养。我们研究的目的是评估咽峡炎抽出物常规培养的价值,并确定由此获得的信息是否具有临床实用性。
我们查阅了英格兰西南部两家医院咽峡炎患者的病历,一家医院的时间跨度为1998年1月至2004年1月,另一家医院为1995年1月至2005年1月。共发现577例病例。其中119例(21%)的抽出脓液被送去培养。对这些病例进行了更详细的检查。
在119例患者中,78.2%(93/119)接受了头孢菌素或青霉素加甲硝唑的治疗。培养出链球菌属的占43.7%(52/119),厌氧菌占23.5%(28/119;其中5.9%(7/119)仅为纯厌氧菌培养)。所有厌氧菌对甲硝唑敏感。119例培养中有1例培养出需氧菌,对青霉素耐药;然而,该患者在青霉素和甲硝唑联合治疗下临床症状有所改善。没有患者因培养结果而改变治疗方案。
根据我们的研究结果(16个医院年度的数据)以及之前的研究(未发现因培养敏感性而改变治疗方案的记录病例),似乎没有必要常规对咽峡炎抽出物进行培养。青霉素或头孢菌素加甲硝唑的联合用药在理论上对我们99.2%(118/119)的标本有效;这一发现得到了其他研究的支持。然而,必须认识到咽峡炎罕见但可能危及生命的并发症。