Polyak Kornelia, Haviv Izhak, Campbell Ian G
Dana-Farber Cancer Institute, 44 Binney Street, D740C, Boston, MA 02115, USA.
Trends Genet. 2009 Jan;25(1):30-8. doi: 10.1016/j.tig.2008.10.012. Epub 2008 Dec 4.
Increasing evidence indicates that tumor-stromal cell interactions have a crucial role in tumor initiation and progression. These interactions modify cellular compartments, leading to the co-evolution of tumor cells and their microenvironment. Although the importance of microenvironmental alterations in tumor development is recognized, the molecular mechanisms underlying these changes are only now beginning to be understood. Epigenetic and gene expression changes have consistently been reported in cancer-associated stromal cells and the influence of the host genotype on tumorigenesis is also well documented. However, the presence of clonally selected somatic genetic alterations within the tumor microenvironment has been controversial. A thorough understanding of the co-evolution of these two cellular compartments will require carefully executed molecular studies combined with mathematical modeling.
越来越多的证据表明，肿瘤-基质细胞相互作用在肿瘤的起始和进展中起着关键作用。这些相互作用改变细胞区室，导致肿瘤细胞与其微环境共同进化。尽管肿瘤发展过程中微环境改变的重要性已得到认可，但这些变化背后的分子机制直到现在才开始被理解。癌症相关基质细胞中一直有表观遗传和基因表达变化的报道，并且宿主基因型对肿瘤发生的影响也有充分记录。然而，肿瘤微环境中克隆选择的体细胞基因改变的存在一直存在争议。要全面了解这两个细胞区室的共同进化，需要精心开展分子研究并结合数学建模。
