Infante-Rivard Claire
Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, 1110 Pine Avenue West, Montréal, Province of Québec, Canada H3A 1A3.
Radiat Prot Dosimetry. 2008;132(2):220-7. doi: 10.1093/rpd/ncn292. Epub 2008 Dec 2.
The search for chemical risks factors as determinants of childhood leukaemia has been ongoing for over two decades. Results of epidemiological studies, published from 1998 to the present, evaluating parental smoking, outdoor sources of pollution, indoor contaminants and chemicals from drinking water are reported. Overall, results were mostly negative. This may be due to the relatively small study sizes to detect environmental effects, usually measured imprecisely. Another reason may be that such effects, which may be revealed among the genetically susceptible, have rarely accounted for genetic susceptibility. The few studies that have are also reported here. Suggestions are made for work in the immediate future, which include pooling of data and of analyses, as well as carrying out in-depth reviews of studies with the goal of understanding the reasons for discrepant results.
对化学风险因素作为儿童白血病决定因素的研究已经持续了二十多年。报告了1998年至今发表的评估父母吸烟、室外污染源、室内污染物和饮用水中化学物质的流行病学研究结果。总体而言，结果大多为阴性。这可能是由于研究规模相对较小，难以检测到环境影响，而且通常测量不够精确。另一个原因可能是，这种影响可能在遗传易感性人群中显现，但很少考虑遗传易感性。这里也报告了少数相关研究。针对近期工作提出了建议，包括数据和分析的汇总，以及对研究进行深入审查，以了解结果不一致的原因。
