Stangel J J, Innerfield I, Reyniak J V, Stone M L
Obstet Gynecol. 1977 Mar;49(3):314-6.
To investigate the effect of conjugated equine estrogens on the coagulability in menopausal women, blood samples were drawn from 69 menopausal females--35 receiving estrogens and 34 receiving no replacement therapy. Using tests for antithrombin and heparin-antithrombin activities, 14.7% of the control patients were found to be hypercoagulable. This is a 289% increase in the incidence of hypercoagulability in the group treated with estrogens. The particular relevance of this finding to menopausal women and the importance of the use of the coagulation profile in managing such patients is discussed.
为研究结合马雌激素对绝经后女性凝血功能的影响，从69名绝经后女性中采集血样——35名接受雌激素治疗，34名未接受替代治疗。通过检测抗凝血酶和肝素-抗凝血酶活性，发现14.7%的对照患者存在高凝状态。在接受雌激素治疗的组中，高凝发生率增加了289%。本文讨论了这一发现与绝经后女性的特殊相关性以及在管理此类患者时使用凝血指标的重要性。
