Clemente C, Russo F, Caruso M G, Giangrande M, Fanizza G, Di Leo A
Laboratorio di Biochimica, I.R.C.C.S.S. de Bellis Castellana G., Bari, Italy.
Horm Metab Res. 1992 Apr;24(4):191-3. doi: 10.1055/s-2007-1003291.
The liver is an estrogen-responsive organ and the administration of estrogens in humans increases the hepatic synthesis of many proteins. The existence of a circadian rhythm of estrogen receptors in the liver has been proved by different authors. We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A. These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens.
肝脏是一个对雌激素有反应的器官，在人类中给予雌激素会增加肝脏中多种蛋白质的合成。不同作者已证实肝脏中雌激素受体存在昼夜节律。我们通过评估血清铜蓝蛋白水平的变化，研究了两组绝经后妇女的肝脏对雌激素的不同反应性。在不同时间给予结合马雌激素（A组：上午8点；B组：晚上8点）。替代疗法使A组和B组的血清铜蓝蛋白水平均升高，但B组的升高幅度高于A组。这些数据间接反映了肝脏对雌激素反应性的昼夜节律的存在。
