Horn Y, Roof B
Oncology. 1976;33(4):188-91. doi: 10.1159/000225140.
Calusterone (7 alpha, 17beta-dimethyltestosterone) is an orally effective weakly androgenic steroid. The antitumor efficacy of calusterone, 200 mg per day against objectively progressing advanced breast cancer in females has already been reported. In the present study calusterone was used in metastatic breast cancer in two male patients. Both had failed to continue respond to orchiectomy and had measurable lesions one in the lungs, the other in the bones. Both patients showed objective regression (blastic response of osteolytic lesions and disappearance of lung metastases) lasting five months in one patients and more than seven months in the other, who is still in regression. Further experience is necessary for statistically adequate results.
卡鲁睾酮（7α,17β - 二甲基睾酮）是一种口服有效的弱雄激素类固醇。已有报道称，卡鲁睾酮每日200毫克对女性客观进展的晚期乳腺癌具有抗肿瘤疗效。在本研究中，卡鲁睾酮用于两名男性转移性乳腺癌患者。两人对睾丸切除术均不再有反应，且有可测量的病灶，一人肺部有病灶，另一人骨骼有病灶。两名患者均出现了客观缓解（溶骨性病灶的成骨反应和肺转移灶消失），其中一名患者的缓解持续了五个月，另一名患者的缓解持续了七个多月且仍在缓解中。为获得统计学上足够的结果，还需要进一步的经验。
