Sapp J P, Brooke R I
Oral Surg Oral Med Oral Pathol. 1977 Mar;43(3):416-21. doi: 10.1016/0030-4220(77)90329-2.
Spherical granular and filamentous intranuclear bodies were found in the marginal epithelial cells of recurrent aphthous ulcers with a herpetiform pattern. They ranged from 0.8 to 1.2 mu in size with one to four bodies being present in any one nucleus. Because of their size and the demonstrated lack of DNA or RNA, it was thought that they were not viral in nature, as has been previously reported. It is hypothesized that intranuclear bodies of the type found in this study represent a common manifestation of altered cellular metabolsim produced by several etiologic factors.
在疱疹样型复发性阿弗他溃疡的边缘上皮细胞中发现了球形颗粒状和丝状核内小体。它们的大小在0.8至1.2微米之间，每个细胞核中存在一至四个小体。由于它们的大小以及已证实缺乏DNA或RNA，因此认为它们本质上不是病毒，正如先前报道的那样。据推测，本研究中发现的这种类型的核内小体代表了由多种病因因素引起的细胞代谢改变的一种常见表现。
