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[脂质体的生物学特性及其实际应用]

[Biological properties of liposomes and their practical application].

作者信息

Halyts'ka S M, Nikol's'kyĭ I S

出版信息

Fiziol Zh (1994). 2008;54(5):99-108.

Abstract

In the review the information about biological properties of liposomes and their application perspectives as independent medications so as transmitters of medicinal preparations is generalized. Approaches to the directed transport of biologically active matters by the different liposome types are discussed. Simultaneously solving of two important tasks on the decline of preparation toxicity and increase of their efficiency are proposed. The data about liposome distributing features at the different ways of their infusion in an organism and the mechanisms of interaction of corpuscles with the surface of target cells are provided. The most perspective aspects of liposomes and drugs in liposomal form at the modern stage of development of biotechnology, pharmacology and immunopharmacology and their practical application in oncology, antibiotic therapies, chemotherapy of infectious diseases, diabetes, gene engineering, treatment of Parkinson's syndrome, creation of artificial oxygen transporters, immunotherapy, allergology, vaccination and other are discussed.

摘要

在这篇综述中,总结了有关脂质体生物学特性及其作为独立药物以及药物制剂传递体的应用前景的信息。讨论了不同类型脂质体对生物活性物质的定向运输方法。提出了同时解决降低制剂毒性和提高其效率这两个重要任务的建议。提供了关于脂质体以不同方式注入机体时的分布特征以及微粒与靶细胞表面相互作用机制的数据。讨论了在生物技术、药理学和免疫药理学发展的现代阶段,脂质体和脂质体形式药物最具前景的方面,以及它们在肿瘤学、抗生素治疗、传染病化疗、糖尿病、基因工程、帕金森综合征治疗、人工氧转运体的创建、免疫疗法、过敏学、疫苗接种等方面的实际应用。

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