Weiner N, Lieb L, Niemiec S, Ramachandran C, Hu Z, Egbaria K
College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.
J Drug Target. 1994;2(5):405-10. doi: 10.3109/10611869408996816.
This review will highlight work done in our laboratories evaluating topical liposomal delivery in a wide variety of animal models and human skin using both in vivo and in vitro techniques. The mechanism by which liposomes facilitate deposition of drugs into the skin and some potential applications of topically applied liposomes will be discussed. Particular emphasis will be placed on the development of analytical techniques that allow the quantification of drug levels in the various skin strata and in pilosebaceous structures. Appropriate models of skin representing the two cases, as well as those wherein both routes are available for skin deposition, were examined using a wide variety of liposomal preparations containing radiolabeled and fluorescent molecules as marker compounds.
本综述将重点介绍我们实验室所开展的工作，这些工作利用体内和体外技术，在多种动物模型和人体皮肤中评估局部脂质体递送。将讨论脂质体促进药物沉积到皮肤中的机制以及局部应用脂质体的一些潜在应用。将特别强调分析技术的发展，这些技术能够对不同皮肤层和毛囊皮脂腺结构中的药物水平进行定量。使用含有放射性标记和荧光分子作为标记化合物的多种脂质体制剂，研究了代表两种情况以及两种途径均可用于皮肤沉积的合适皮肤模型。
