Simesen M G
Nord Vet Med. 1977 Feb;29(2):76-89.
A review is given of the literature concerning the so-called plant induced calcinosis in animals (tabel I), i.e. diseases which in their patological-anatomical appearance show great similarities with vit. D-intoxication. The etiology of the diseases are discussed in view of the last 5--10 years rapid development of knowledge concerning vit. D3 metabolism. It is pointed out that the most recent results indicate that enzootic calcinosis is caused by a 1,25-dihydrocholecalciferol-glycoside, which is hydrolysed in the intestinal tract. By this reaction 1.25 (OH) 2 cholecalciferol--the biological active metabolite of vit. D3 -- is set free, and thus able to act directly on the intestinal absorption mechanism. By this reaction the point of calcium metabolism regulation is essentially by-passed and calcium and phosphate absorption proceeds essentially out of control, causing hypercalcaemia, hyperphosphataemia, hypersecretion of calcitonin and calcinosis.
对有关动物所谓的植物性诱导钙化症（表一）的文献进行了综述，即那些在病理解剖学表现上与维生素D中毒有很大相似性的疾病。鉴于过去5至10年中关于维生素D3代谢的知识迅速发展，对这些疾病的病因进行了讨论。指出最新结果表明，地方性钙化症是由一种在肠道中水解的1,25 - 二氢胆钙化醇糖苷引起的。通过这种反应，维生素D3的生物活性代谢物1,25(OH)2胆钙化醇被释放出来，从而能够直接作用于肠道吸收机制。通过这种反应，钙代谢调节点基本上被绕过，钙和磷的吸收基本上失去控制，导致高钙血症、高磷血症、降钙素分泌过多和钙化症。
