de Vernejoul M C, Mautalen C A, Miravet L
Nouv Presse Med. 1978 Jun 3;7(22):1941-3.
The solanum molacoxylon (SM) is a plant which grows in South America, whose leaves produce a calcinosis on animal farms. In the aquous extract of the leaves a glycoside of 1, 25 (OH)2D3 has been found. The aquous extracts of the leaves of SM provokes an increase of intestinal calcium absorption without any transformation, because it is active in total nephrectomized animal. If this extract is given during a short time the bone resorption is dramatically increased, nevertheless if it is given chronically an increase of bone formation with an osteosclerosis is observed. This plant increases the plasma and urinary calcium and sometimes the plasma phosphorus. In acute administration the urinary hydroxyproline increases. A few therapeutic assays were done in humans with similar results. These assays suggest that SM could be a natural source of 1,25 dihydroxycholecalciferol.
莫拉可西龙茄（SM）是一种生长在南美洲的植物，其叶子会在养殖场导致动物钙质沉着。在叶子的水提取物中发现了1,25（OH）₂D₃的一种糖苷。SM叶子的水提取物能在不经任何转化的情况下促进肠道对钙的吸收，因为它在全肾切除的动物中具有活性。如果短期内给予这种提取物，骨吸收会显著增加，然而如果长期给予，则会观察到骨形成增加并伴有骨硬化。这种植物会使血浆和尿液中的钙增加，有时也会使血浆磷增加。急性给药时尿羟脯氨酸会增加。在人体进行了一些治疗试验，结果相似。这些试验表明，SM可能是1,25 - 二羟胆钙化醇的天然来源。
