Webster Lynn R
Lifetree Clinical Research and Pain Clinic, 3838 South, 700 East, Suite 200, Salt Lake City, UT 84106, USA.
Clin Lab Med. 2008 Dec;28(4):569-79. doi: 10.1016/j.cll.2008.05.005.
Genetic research heralds a new therapeutic approach to pain management. Increasing literature demonstrates individual genetic vulnerabilities to specific pain types and mechanisms, partially explaining differing responses to similar pain stimuli. Furthermore, analgesics demonstrate great variability among polymorphic genotypes. Family history and genotyping promise to play an important role in future pain therapies. As advances continue in the genetics of pain and analgesia, pharmacotherapy will depend more on an individualized, targeted approach and less on empiricism.
基因研究预示着疼痛管理的一种新治疗方法。越来越多的文献表明个体对特定疼痛类型和机制存在基因易感性，这部分解释了对相似疼痛刺激的不同反应。此外，镇痛药在多态基因型之间表现出很大的变异性。家族史和基因分型有望在未来的疼痛治疗中发挥重要作用。随着疼痛与镇痛遗传学的不断进展，药物治疗将更多地依赖个体化、靶向性方法，而较少依赖经验主义。
