Dickkopf-4常被下调并抑制结肠癌细胞的生长。
Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
作者信息
Baehs Sebastian, Herbst Andreas, Thieme Susanne E, Perschl Claudia, Behrens Andrea, Scheel Silvio, Jung Andreas, Brabletz Thomas, Göke Burkhard, Blum Helmut, Kolligs Frank T
机构信息
Department of Medicine II, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, Munich, Germany.
出版信息
Cancer Lett. 2009 Apr 18;276(2):152-9. doi: 10.1016/j.canlet.2008.11.003. Epub 2008 Dec 6.
Like Dickkopf-1 (DKK1), DKK4 is a target of beta-catenin/Tcf-4 in colorectal cancer. However, as a negative regulator of Wnt signalling its function in colorectal cancer cells is not well understood. We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated beta-catenin/Tcf-4 and in primary colorectal cancers. Exposure of cancer cells to DKK4 strongly inhibits basal beta-catenin/Tcf-4 signalling activity, cancer cell growth and cell cycle progression. Therefore, loss of this negative feed-back loop provides Wnt factor expressing cancer cells with a growth advantage. Our data demonstrate that DKK4 is an important negative regulator of colon cancer cell growth.
与Dickkopf-1（DKK1）一样，DKK4是结直肠癌中β-连环蛋白/Tcf-4的一个靶点。然而，作为Wnt信号通路的负调节因子，其在结直肠癌细胞中的功能尚未完全明确。我们报告称，在β-连环蛋白/Tcf-4失调的结直肠癌细胞系以及原发性结直肠癌中，DKK4经常下调。将癌细胞暴露于DKK4可强烈抑制基础β-连环蛋白/Tcf-4信号活性、癌细胞生长和细胞周期进程。因此，这种负反馈环的缺失为表达Wnt因子的癌细胞提供了生长优势。我们的数据表明，DKK4是结肠癌细胞生长的重要负调节因子。
Zotero 插件