Porter John, Lumb Simon, Lecomte Fabien, Reuberson James, Foley Anne, Calmiano Mark, le Riche Kelly, Edwards Helen, Delgado Jean, Franklin Richard J, Gascon-Simorte Jose M, Maloney Alison, Meier Christoph, Batchelor Mark
UCB Celltech, 216 Bath Road, Slough SL1 3WE, United Kingdom.
Bioorg Med Chem Lett. 2009 Jan 15;19(2):397-400. doi: 10.1016/j.bmcl.2008.11.062. Epub 2008 Nov 21.
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.
本文描述了一系列c-Met激酶的喹喔啉抑制剂。通过X射线晶体结构证实了假定的结合模式，并基于该结构对该系列进行了优化。讨论了该系列的未来发展方向以及一种新型喹啉骨架的鉴定。
