化疗所致腹泻患者的肠道通透性与维生素A吸收情况

Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.

作者信息

Melichar Bohuslav, Dvorák Josef, Krcmová Lenka, Hyspler Radomír, Urbánek Lubor, Solichová Dagmar

机构信息

Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic.

出版信息

Am J Clin Oncol. 2008 Dec;31(6):580-4. doi: 10.1097/COC.0b013e318174dbb9.

DOI:10.1097/COC.0b013e318174dbb9

PMID:19060591

Abstract

OBJECTIVE

Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID).

METHODS

We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test.

RESULTS

Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID.

CONCLUSIONS

Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID.

摘要

目的

胃肠道毒性是抗癌治疗最常见的副作用之一。测量肠道通透性是胃肠道毒性非侵入性实验室评估的潜在方法之一。本研究的目的是调查化疗引起的腹泻（CID）患者的肠道通透性和维生素A吸收情况。

方法

我们通过测量乳果糖、甘露醇、木糖的吸收来评估肠道通透性以及维生素A吸收情况，研究对象包括11例CID患者、10名健康对照者和24例未经治疗的胃肠道肿瘤患者。尿中乳果糖、甘露醇和木糖通过毛细管气相色谱法测量，血清视黄醇和视黄酯通过高效液相色谱法测定。患者和对照者的结果通过Mann-Whitney U检验进行比较。