Correa Denise D, Ahles Tim A
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA.
Cancer J. 2008 Nov-Dec;14(6):396-400. doi: 10.1097/PPO.0b013e31818d8769.
This article provides an overview of the most recent literature on the cognitive adverse effects of chemotherapy in patients with breast cancer. The prevalence of cognitive dysfunction in patients treated with chemotherapy was variable in studies using a cross-sectional design. More recent prospective studies detected cognitive difficulties in subgroups of patients, mostly at short-term follow-ups, but other studies found no evidence of impairment. Studies using neuroimaging techniques and animal models have begun to examine structural and functional correlates of cognitive changes associated with chemotherapy. A review of the literature suggests that considerable progress has been made in the investigation of chemotherapy-related cognitive dysfunction in recent years, and highlights the importance of a multidisciplinary approach to further elucidate the mechanisms that may underlie treatment-related toxicity.
本文概述了关于乳腺癌患者化疗认知不良反应的最新文献。在采用横断面设计的研究中，接受化疗患者的认知功能障碍患病率各不相同。最近的前瞻性研究在部分患者亚组中发现了认知困难，大多是在短期随访中，但其他研究未发现受损证据。使用神经成像技术和动物模型的研究已开始探究与化疗相关的认知变化的结构和功能相关性。文献综述表明，近年来在化疗相关认知功能障碍的研究方面取得了显著进展，并强调了多学科方法对于进一步阐明可能构成治疗相关毒性基础的机制的重要性。
