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吉非贝齐（CI - 719）的脂肪动力学研究。

Lipokinetic studies with gemfibrozil (CI-719).

作者信息

Kissebah A H, Adams P A, Wynn V

出版信息

Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):94-7. doi: 10.1177/00359157760690S224.

DOI:10.1177/00359157760690S224
PMID:190610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1864040/
Abstract

Gemfibrozil (CI-719) has proved to be an effective agent in reducing the plasma triglyceride levels in experimental animals and in patients with endogenous hypertriglyceridaemia. We have confirmed these findings.

摘要

吉非贝齐（CI - 719）已被证明是一种有效降低实验动物和内源性高甘油三酯血症患者血浆甘油三酯水平的药物。我们已证实了这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd7/1864040/a2bd01440384/procrsmed00035-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd7/1864040/a2bd01440384/procrsmed00035-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd7/1864040/a2bd01440384/procrsmed00035-0101-a.jpg

相似文献

1
Lipokinetic studies with gemfibrozil (CI-719).吉非贝齐（CI - 719）的脂肪动力学研究。
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):94-7. doi: 10.1177/00359157760690S224.
2
Effect of gemfibrozil on lipolysis in dogs in vivo.吉非贝齐对犬体内脂肪分解的影响。
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):107-8. doi: 10.1177/00359157760690S228.
3
Gemfibrozil: a new lipid lowering agent. Open forum.吉非贝齐：一种新型降脂药。公开论坛。
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):115-20. doi: 10.1177/00359157760690S231.
4
The hypolipidaemic effect of gemfibrozil (CI-719) in laboratory animals.吉非贝齐（CI - 719）对实验动物的降血脂作用。
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):6-10. doi: 10.1177/00359157760690S203.
5
Properties of sterol biosynthesis in human leukocytes: effects of gemfibrozil.人白细胞中甾醇生物合成的特性：吉非贝齐的作用
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):104-6. doi: 10.1177/00359157760690S227.
6
Preliminary observations on the effect of gemfibrozil on the excretion of faecal bile acids.吉非贝齐对粪便胆汁酸排泄影响的初步观察
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):112-4. doi: 10.1177/00359157760690S230.
7
Gemfibrozil treatment: a comparison with clofibrate.
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):88-9. doi: 10.1177/00359157760690S222.
8
Toleration and bioavailability of gemfibrozil in healthy men.吉非贝齐在健康男性中的耐受性和生物利用度。
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):24-7. doi: 10.1177/00359157760690S206.
9
The effect of Gemfibrozil on human serum apolipoproteins and on serum reserve cholesterol binding capacity (SRCBC).吉非贝齐对人血清载脂蛋白及血清储备胆固醇结合能力（SRCBC）的影响。
Artery. 1981;9(1):77-86.
10
Effects of gemfibrozil on plasma lipoprotein-apolipoprotein distribution and platelet reactivity in patients with hypertriglyceridemia.吉非贝齐对高甘油三酯血症患者血浆脂蛋白 - 载脂蛋白分布及血小板反应性的影响。
J Lab Clin Med. 1987 Sep;110(3):279-86.

引用本文的文献

1
Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in type 2 (non-insulin-dependent) diabetic patients.
Diabetologia. 1993 Feb;36(2):161-9. doi: 10.1007/BF00400699.
2
Gemfibrozil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia.吉非贝齐。对其药效学和药代动力学特性以及在血脂异常治疗中的应用综述。
Drugs. 1988 Sep;36(3):314-39. doi: 10.2165/00003495-198836030-00004.

本文引用的文献

1
Precursors of plasma triglyceride fatty acid in humans. Effects of glucose consumption, clofibrate administration, and alcoholic fatty liver.
Metabolism. 1972 Feb;21(2):117-24. doi: 10.1016/0026-0495(72)90063-7.
2
The mechanism of action of clofibrate and tetranicotinoylfructose (Bradilan) on the kinetics of plasma free fatty acid and triglyceride transport in type IV and type V hypertriglyceridaemia.氯贝丁酯和四烟酰果糖（布拉地兰）对IV型和V型高甘油三酯血症患者血浆游离脂肪酸和甘油三酯转运动力学的作用机制。
Eur J Clin Invest. 1974 Jun;4(3):163-74. doi: 10.1111/j.1365-2362.1974.tb00387.x.
3
The kinetics of plasma free fatty acid and triglyceride transport in patients with idiopathic hypertriglyceridaemia and their relation to carbohydrate metabolism.
Eur J Clin Invest. 1974 Jun;4(3):149-61. doi: 10.1111/j.1365-2362.1974.tb00386.x.
4
Plasma free fatty acid and triglyceride transport kinetics in man.人体血浆游离脂肪酸和甘油三酯的转运动力学
Clin Sci Mol Med. 1974 Sep;47(3):259-78. doi: 10.1042/cs0470259.
5
Metabolism of rat plasma very low density lipoprotein. I. Fate in circulation of the whole lipoprotein.
Biochim Biophys Acta. 1973 Dec 20;326(3):378-90. doi: 10.1016/0005-2760(73)90139-2.
6
Precursors of plasma triglyceride fatty acids in obesity.肥胖症中血浆甘油三酯脂肪酸的前体
Metabolism. 1973 Jun;22(6):779-83. doi: 10.1016/0026-0495(73)90048-6.
7
The metabolic fate of plasma lipoproteins in normal subjects and in patients with insulin resistance and endogenous hypertriglyceridaemia.正常受试者以及胰岛素抵抗和内源性高甘油三酯血症患者血浆脂蛋白的代谢命运。
Diabetologia. 1976 Oct;12(5):501-9. doi: 10.1007/BF01219515.
8
Transport kinetics of plasma free fatty acid, very low density lipoprotein triglycerides and apoprotein in patients with endogenous hypertriglyceridaemia: effects of 2,2-dimethyl, 5(2, 5-xylyoxy) valeric acid therapy.内源性高甘油三酯血症患者血浆游离脂肪酸、极低密度脂蛋白甘油三酯及载脂蛋白的转运动力学：2,2 - 二甲基 - 5(2,5 - 二甲苯氧基)戊酸治疗的影响
Atherosclerosis. 1976 Jul-Aug;24(1-2):199-218. doi: 10.1016/0021-9150(76)90076-9.