Johnson Hillary, Bossenbroek Nicole M, Rosenman Karla, Meehan Shane A, Robles Mirin, Pomeranz Miriam K
Department of Dermatology, New York University, USA.
Dermatol Online J. 2008 Oct 15;14(10):10.
A 49-year-old woman presented with a seven-year history of pruritic, erythematous, scaling plaques on sun-exposed skin that localized only to pre-existing depigmented patches. Histopathologic examination showed changes consistent with cutaneous lupus erythematosus with lichenoid features and confirmed contiguous vitiligo. Diagnosis of chronic cutaneous lupus erythematosus localized to areas of vitiligo was determined by clinicopathologic correlation and may reflect an autoimmune diathesis. Consequently, hydroxychloroquine and topical glucocorticoids therapy were initiated with reported improvement in pruritus, erythema, and scale. Clinical monitoring for development of squamous-cell carcinoma in areas of chronic inflammation and sun-exposure is imperative.
一名49岁女性，有7年病史，在暴露于阳光下的皮肤上出现瘙痒性、红斑性、鳞屑性斑块，这些斑块仅局限于先前存在的色素脱失斑。组织病理学检查显示的变化符合具有苔藓样特征的皮肤红斑狼疮，并证实存在相邻的白癜风。通过临床病理相关性确定了局限于白癜风区域的慢性皮肤红斑狼疮的诊断，这可能反映了一种自身免疫素质。因此，开始使用羟氯喹和外用糖皮质激素治疗，据报道瘙痒、红斑和鳞屑有所改善。对慢性炎症和阳光暴露区域进行鳞状细胞癌发生情况的临床监测至关重要。
