肾上腺素与勃起功能障碍和下尿路症状都有关。
Epinephrine is associated with both erectile dysfunction and lower urinary tract symptoms.
机构信息
Division of Urology, Penn State Milton S. Hershey Medical Center, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA.
出版信息
Fertil Steril. 2010 Feb;93(3):837-42. doi: 10.1016/j.fertnstert.2008.10.034. Epub 2008 Dec 4.
OBJECTIVE
To determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls.
DESIGN
Prospective case-control study.
SETTING
Academic medical center.
PATIENT(S): Twenty-nine nondiabetic men aged 18-66 years were enrolled. Of these, 28 completed the study: 17 had ED, and 11 did not.
INTERVENTION(S): Validated ED questionnaires, examination, serum hormones evaluation, and oral glucose tolerance testing.
MAIN OUTCOME MEASURE(S): Association of IR with ED.
RESULT(S): The association between worsening degrees of both lower urinary tract symptoms (LUTS) and ED was reaffirmed, as was a potential correlation between the two-epinephrine. There was a negative association between serum levels of epinephrine and scores on the 5-item version of the International Index of Erectile Dysfunction for ED (Spearman correlation coefficient = -0.38). On the other hand, men with ED were not more likely to have IR compared with controls.
CONCLUSION(S): Epinephrine may be the common link between ED and LUTS.
目的
与对照组相比，确定勃起功能障碍（ED）患者是否具有更高的胰岛素抵抗（IR）发生率。
设计
前瞻性病例对照研究。
地点
学术医疗中心。
患者
共纳入 29 名年龄在 18-66 岁之间的非糖尿病男性。其中 28 名完成了研究：17 名患有 ED，11 名未患有 ED。
干预措施
经过验证的 ED 问卷、检查、血清激素评估和口服葡萄糖耐量试验。
主要观察指标
IR 与 ED 的关联。
结果
再次证实了下尿路症状（LUTS）和 ED 的严重程度之间的关联，以及两者之间的肾上腺素潜在相关性。血清肾上腺素水平与 ED 的 5 项国际勃起功能指数（5-item version of the International Index of Erectile Dysfunction for ED）评分呈负相关（Spearman 相关系数=-0.38）。另一方面，与对照组相比，ED 患者并不更可能出现 IR。
结论
肾上腺素可能是 ED 和 LUTS 之间的共同联系。
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