Varga M, Babovic A, Flekkoy K, Ronneberg U, Landro N I, David A S, Opjordsmoen S
Department of Acute Psychiatric Emergency Ward, Aker University Hospital, Oslo, Norway.
J Affect Disord. 2009 Jul;116(1-2):56-63. doi: 10.1016/j.jad.2008.11.005. Epub 2008 Dec 5.
To correlate measures of insight for own psychopathology to structural and functional brain imaging findings in 21 patients with DSM-IV bipolar I disorder.
Insight was assessed using the Scale to Assess Unawareness of Mental Disorder (SUMD). Resting single photon emission computed tomography (SPECT) and computed tomography (CT) was conducted in patients and 21 normal comparison subjects matched for age, gender and handedness.
Reduced general insight and symptom awareness, but not symptom attribution, were significantly related to cortical and subcortical atrophy, respectively. No correlations between SPECT and insight measures were identified.
Limited sample size and the use of resting state SPECT.
General and symptom awareness were related to measures of brain atrophy but not to neurofunctioning as measured by SPECT. Future research should consider the structure and function of specific cortical regions, including the frontal and parietal cortices.
将21例DSM-IV双相I型障碍患者对自身精神病理学的自知力测量结果与脑结构和功能成像结果进行关联。
使用精神障碍自知力评定量表（SUMD）评估自知力。对患者以及21名年龄、性别和利手相匹配的正常对照者进行静息态单光子发射计算机断层扫描（SPECT）和计算机断层扫描（CT）。
总体自知力和症状自知力降低，但症状归因能力未降低，分别与皮质和皮质下萎缩显著相关。未发现SPECT与自知力测量结果之间存在相关性。
样本量有限且使用静息态SPECT。
总体自知力和症状自知力与脑萎缩测量结果相关，但与SPECT测量的神经功能无关。未来的研究应考虑特定皮质区域的结构和功能，包括额叶和顶叶皮质。
