Kahl Kai G, Bens Susanne, Ziegler Kristin, Rudolf Sebastian, Kordon Andreas, Dibbelt Leif, Schweiger Ulrich
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Psychoneuroendocrinology. 2009 Apr;34(3):353-7. doi: 10.1016/j.psyneuen.2008.09.016. Epub 2008 Dec 4.
Major depression has been associated with endocrine and immune alterations, in particular a dysregulation of the hypothalamus-pituitary-adrenal system with subsequent hypercortisolism and an imbalance of pro- and anti-inflammatory cytokines. Recent studies suggest that vascular endothelial growth factor (VEGF), a cytokine involved in angiogenesis and neurogenesis, may also be dysregulated during stress and depression. These observations prompted us to examine VEGF and other angiogenic factors in patients with major depressive disorder.
Twelve medication-free female patients with a major depressive episode in the context of borderline personality disorder (MDD/BPD) and twelve healthy women were included. Concentrations of VEGF, VEGF receptors 1 and 2, basic fibroblast growth factor-2 (FGF-2), hepatocyte growth factor (HGF), angiopoetin-2, interleukin-8 (IL-8) and transforming growth factor-beta1 (TGF-beta1) were determined from serum profiles.
Increased concentrations of VEGF and FGF-2 were found in MDD/BPD patients compared to the healthy comparator group. No group differences were found concerning the other angiogenic factors examined.
Depressive episodes in the context of borderline personality disorder may be accompanied by increased serum concentrations of VEGF and FGF-2. Similar findings have been observed in patients with major depression without a borderline personality disorder. A dysregulation of angiogenic factors may be another facet of the endocrine and immunologic disturbances frequently seen in patients with depressive episodes.
重度抑郁症与内分泌和免疫改变有关，尤其是下丘脑 - 垂体 - 肾上腺系统失调，继而导致高皮质醇血症以及促炎和抗炎细胞因子失衡。最近的研究表明，血管内皮生长因子（VEGF），一种参与血管生成和神经发生的细胞因子，在应激和抑郁期间也可能失调。这些观察结果促使我们研究重度抑郁症患者的VEGF和其他血管生成因子。
纳入12名无药物治疗的边缘型人格障碍伴重度抑郁发作的女性患者（MDD/BPD）和12名健康女性。从血清样本中测定VEGF、VEGF受体1和2、碱性成纤维细胞生长因子 - 2（FGF - 2）、肝细胞生长因子（HGF）、血管生成素 - 2、白细胞介素 - 8（IL - 8）和转化生长因子 - β1（TGF - β1）的浓度。
与健康对照组相比，MDD/BPD患者的VEGF和FGF - 2浓度升高。在所检测的其他血管生成因子方面未发现组间差异。
边缘型人格障碍伴发的抑郁发作可能伴有血清VEGF和FGF - 2浓度升高。在无边缘型人格障碍的重度抑郁症患者中也观察到了类似的发现。血管生成因子失调可能是抑郁发作患者常见的内分泌和免疫紊乱的另一个方面。
