肾上腺素对正常及抗原致敏豚鼠肺组织中环磷酸腺苷水平、腺苷酸环化酶及磷酸二酯酶活性的影响。
Effect of epinephrine on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in control and antigen-sensitized guinea pig lungs.
作者信息
Mathé A A, Puri S K, Volicer L, Sohn R J
出版信息
Pharmacology. 1976;14(6):511-21. doi: 10.1159/000136636.
Cyclic AMP levels and adenylate cyclase and phosphodiesterase activities were measured in control and ovalbumin-sensitized guinea pig lungs. Cyclic AMP levels were raised by epinephrine (0.01-10 mug/ml) in both control and sensitized lungs; the response being larger in the former group. Epinephrine (10(-9) -10(-6) M) stimulated adenylate cyclase in sensitized but had only a minimal effect in control preparations. Phosphodiesterase activities were equal in both groups. The hypersensitivity of adenylate cyclase response to epinephrine concurrent with diminished accumulation of cyclic AMP in sensitized guinea pigs indicate that antigen sensitization alters the response of the cyclic AMP system to epinephrine.
在对照和卵清蛋白致敏的豚鼠肺中测量了环磷酸腺苷（cAMP）水平以及腺苷酸环化酶和磷酸二酯酶的活性。在对照肺和致敏肺中，肾上腺素（0.01 - 10微克/毫升）均可提高cAMP水平；前一组的反应更大。肾上腺素（10⁻⁹ - 10⁻⁶ M）刺激致敏肺中的腺苷酸环化酶，但对对照制剂仅有最小的作用。两组的磷酸二酯酶活性相等。致敏豚鼠中腺苷酸环化酶对肾上腺素反应的超敏性与cAMP积累减少同时出现，表明抗原致敏改变了cAMP系统对肾上腺素的反应。
Zotero 插件