比较四种血液学分析仪CELL-DYN Sapphire、ADVIA 120、库尔特LH 750和希森美康XE-2100在临床实用性方面的表现。

Comparison of four hematology analyzers, CELL-DYN Sapphire, ADVIA 120, Coulter LH 750, and Sysmex XE-2100, in terms of clinical usefulness.

作者信息

Kang S H, Kim H K, Ham C K, Lee D S, Cho H I

机构信息

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Int J Lab Hematol. 2008 Dec;30(6):480-6.

PMID:19062362

Abstract

We evaluated the clinical usefulness (leukocyte distribution classification, morphologic classification, and morphologic flags) of the following four hematology analyzers: CELL-DYN Sapphire (CD-Sapphire) (Abbott Diagnostics, Santa Clara, CA, USA), ADVIA 120 (Bayer Diagnostics, Tarrytown, NY, USA), Beckman Coulter LH 750 (Beckman Coulter, Miami, FL, USA), and Sysmex XE-2100 (TOA Medical Electronics Co., Kobe, Japan). Four hundred thirty samples from patients and 100 samples from healthy individuals were analyzed. For distributional classification, the sensitivity rates of CD-Sapphire, ADVIA 120, LH 750, and XE-2100 were 93.1, 95.9, 94.9, and 94.9%, respectively, and the efficiency rates were 80.7, 81.6, 84.1, and 84.2%, respectively. For morphologic classification, the sensitivity rates of CD-Sapphire, ADVIA 120, LH 750, and XE-2100 were 88.6, 93.2, 77.3, and 94.3%, respectively, and the efficiency rates were 80.9, 73.0, 79.5, and 74.2%, respectively. Comparing the findings in different morphologic flags, XE-2100 showed the highest sensitivity for Blasts flag (90.9%); CD-Sapphire showed the highest sensitivity for Immature granulocytes and/or Left-shift flag (85.5%); ADVIA 120 showed the highest sensitivity for Atypical lymphocytes flag (60.0%); and LH 750 showed the highest sensitivity for Nucleated RBC flag (75.0%). Our results demonstrate that the four analyzers are comparable in overall performance.

摘要

我们评估了以下四款血液分析仪的临床实用性（白细胞分布分类、形态学分类和形态学标记）：CELL-DYN Sapphire（CD-Sapphire）（美国加利福尼亚州圣克拉拉市雅培诊断公司）、ADVIA 120（美国纽约州塔里敦市拜耳诊断公司）、贝克曼库尔特LH 750（美国佛罗里达州迈阿密市贝克曼库尔特公司）和Sysmex XE-2100（日本神户市东亚医用电子株式会社）。分析了来自患者的430份样本和来自健康个体的100份样本。对于分布分类，CD-Sapphire、ADVIA 120、LH 750和XE-2100的灵敏度分别为93.1%、95.9%、94.9%和94.9%，效率分别为80.7%、81.6%、84.1%和84.2%。对于形态学分类，CD-Sapphire、ADVIA 120、LH 750和XE-2100的灵敏度分别为88.6%、93.2%、77.3%和94.3%，效率分别为80.9%、73.0%、79.5%和74.2%。比较不同形态学标记的结果，XE-2100对原始细胞标记显示出最高灵敏度（90.9%）；CD-Sapphire对未成熟粒细胞和/或核左移标记显示出最高灵敏度（85.5%）；ADVIA 120对异型淋巴细胞标记显示出最高灵敏度（60.0%）；LH 750对有核红细胞标记显示出最高灵敏度（75.0%）。我们的结果表明，这四款分析仪在整体性能上具有可比性。