铜绿假单胞菌PAO中对亚胺培南的耐药性：OprD2基因图谱
Imipenem resistance in pseudomonas aeruginosa PAO: mapping of the OprD2 gene.
作者信息
Quinn J P, Darzins A, Miyashiro D, Ripp S, Miller R V
机构信息
Department of Medicine, Michael Reese Hospital, Chicago, Illinois 60616.
出版信息
Antimicrob Agents Chemother. 1991 Apr;35(4):753-5. doi: 10.1128/AAC.35.4.753.
Abstract
Carbapenem antibiotics have been shown to penetrate the outer membrane of Pseudomonas aeruginosa through a unique porin protein, OprD2. We mapped the OprD2 gene by conjugation using plasmid FP2 and by transduction using phage F116L. This gene maps between 71 and 75 min on the PAO1 chromosome.
摘要
碳青霉烯类抗生素已被证明可通过一种独特的孔蛋白OprD2穿透铜绿假单胞菌的外膜。我们通过使用质粒FP2的接合转移和使用噬菌体F116L的转导来定位OprD2基因。该基因定位于PAO1染色体上71至75分钟之间。
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