Kulsuntiwong Panthong, Chomvarin Chariya, Chaicumpar Kunyaluk, Namwat Wises, Kaewkes Wanlop, Mairiang Pisaln, Sangchan Apichat
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Southeast Asian J Trop Med Public Health. 2008 Nov;39(6):1102-9.
The objective of this study was to evaluate the prevalence of antimicrobial resistance in Helicobacter pylori isolated from the antrum and corpus of dyspeptic patients in Khon Kaen, Thailand, and to compare the antimicrobial susceptibility patterns of H. pylori isolated from the antrum and corpus in individual patients. Antimicrobial susceptibility was determined by disk diffusion, studying susceptibility to metronidazole, clarithromycin, amoxicillin, erythromycin, ciprofloxacin, and tetracycline. The H. pylori resistant rate to at least one of the six antimicrobial agents tested was 37%. The resistance rates were 30.2% for metronidazole, 9.2% for ciprofloxacin, 5% for clarithromycin, 2.4% for amoxicillin, and 1.7% for erythromycin and tetracycline. Single, double, and more than double antimicrobial resistances were found in 27.7, 6.7 and 2.5%, respectively. Antimicrobial susceptibility testing revealed 11 antibiotypes. The most common antimicrobial susceptibility pattern found was sensitivity to 6 antimicrobial agents (63%). H. pylori antimicrobial resistance in specimens isolated from the antrum and corpus were nearly equivalent, 37.3% (22/59) and 36.7% (22/60), respectively. Most of the H. pylori specimens isolated from the antrum and corpus in individual patients were identical (87.7%).
本研究的目的是评估从泰国孔敬消化不良患者的胃窦和胃体分离出的幽门螺杆菌的抗菌药物耐药性流行情况，并比较个体患者胃窦和胃体分离出的幽门螺杆菌的抗菌药物敏感性模式。通过纸片扩散法测定抗菌药物敏感性，研究对甲硝唑、克拉霉素、阿莫西林、红霉素、环丙沙星和四环素的敏感性。幽门螺杆菌对所测试的六种抗菌药物中至少一种的耐药率为37%。甲硝唑的耐药率为30.2%，环丙沙星为9.2%，克拉霉素为5%，阿莫西林为2.4%，红霉素和四环素为1.7%。分别发现单药、双药和多药耐药的比例为27.7%、6.7%和2.5%。抗菌药物敏感性测试显示有11种抗菌谱型。最常见的抗菌药物敏感性模式是对6种抗菌药物敏感（63%）。从胃窦和胃体分离的标本中幽门螺杆菌的抗菌药物耐药性几乎相当，分别为37.3%（22/59）和36.7%（22/60）。在个体患者中，从胃窦和胃体分离出的大多数幽门螺杆菌标本是相同的（87.7%）。
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