Abdulrasheed Abdul, Lawal O O, Abioye-Kuteyi E A, Lamikanra A
Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria.
Trop Gastroenterol. 2005 Apr-Jun;26(2):85-8.
The resistance of Helicobacter pylori to antibiotic treatment is a growing global concern, but this has not been well studied in our environment. This study sought to determine: the susceptibility of the organism to common antimicrobial agents used in its eradication therapy. Twenty H. pylori isolates from dyspeptic patients were subjected to standard procedures for sensitivity testing and the determination of minimum inhibitory concentration against amoxycillin, ciprofloxacin, clarithromycin, erythromycin, metronidazole, rifampicin and tetracycline. The study showed marked in vitro multiple antimicrobial resistance to the commonly used eradication agents. All twenty isolates were however sensitive to ciprofloxacin. The findings of marked antimicrobial resistance may affect the effectiveness of currently recommended eradication regimes. In our environment, incorporating ciprofloxacin into the existing H. pylori antimicrobial therapy may improve the outcome of eradication.
幽门螺杆菌对抗生素治疗的耐药性是一个日益引起全球关注的问题，但在我们所处的环境中对此尚未进行充分研究。本研究旨在确定：该生物体对其根除治疗中常用抗菌药物的敏感性。对20株来自消化不良患者的幽门螺杆菌分离株进行标准程序的药敏试验，并测定其对阿莫西林、环丙沙星、克拉霉素、红霉素、甲硝唑、利福平和四环素的最低抑菌浓度。研究表明，这些分离株对常用的根除药物存在明显的体外多重耐药性。然而，所有20株分离株对环丙沙星敏感。显著的抗菌药物耐药性这一发现可能会影响目前推荐的根除方案的有效性。在我们所处的环境中，将环丙沙星纳入现有的幽门螺杆菌抗菌治疗方案中可能会改善根除效果。
