幽门螺杆菌分离株对氟喹诺酮类、阿莫西林、克拉霉素和甲硝唑的耐药模式。

Patterns of Helicobacter pylori isolate resistance to fluoroquinolones, amoxicillin, clarithromycin and metronidazoles.

作者信息

Kumala Widyasari, Rani Aziz

机构信息

Department of Microbiology, Faculty of Medicine, Trisakti University, Kyai Tapa, no 260 (Kampus B) Grogol, 11440, Jakarta, Indonesia.

出版信息

Southeast Asian J Trop Med Public Health. 2006 Sep;37(5):970-4.

PMID:17333742

Abstract

Helicobacter pylori eradication using the three antibiotic regimen of amoxicillin, clarithromycin and metronidazole often fails, making it imperative to find substitutes. The following study made use of 72 H. pylori isolates derived from pyloric antrum mucosa biopsies of gastritis and chronic dyspepsia patients treated at the Cipto Mangunkusumo National General Hospital and three private hospitals in Jakarta. Testing for H. pylori sensitivity to various antimicrobials was conducted using the disk diffusion method (Kirby Bauer) and procedures determined by the Clinical and Laboratory Standards Intitute (CLSI)/NCCLS. The resistance rates of the isolates were 100% for metronodazole, 27.8% for clarithromycin, 19.4% for amoxicillin, 6.9% for ciprofloxacin, norfloxacin and ofloxacin, 2.8% for sparfloxacin and gatifloxacin, and 1.4% for levofloxacin and moxifloxacin. Fluoroquinolons have the lowest resistance compared to amoxicillin, clarithromycin and metronidazole.

摘要

使用阿莫西林、克拉霉素和甲硝唑的三联抗生素疗法根除幽门螺杆菌常常失败，因此必须找到替代药物。以下研究使用了72株幽门螺杆菌分离株，这些分离株来自于在雅加达的Cipto Mangunkusumo国家综合医院和三家私立医院接受治疗的胃炎和慢性消化不良患者的幽门窦黏膜活检样本。采用纸片扩散法（Kirby Bauer法）以及临床和实验室标准协会（CLSI）/美国国家临床实验室标准委员会（NCCLS）规定的程序，对幽门螺杆菌对各种抗菌药物的敏感性进行检测。分离株对甲硝唑的耐药率为100%，对克拉霉素的耐药率为27.8%，对阿莫西林的耐药率为19.4%，对环丙沙星、诺氟沙星和氧氟沙星的耐药率为6.9%，对司帕沙星和加替沙星的耐药率为2.8%，对左氧氟沙星和莫西沙星的耐药率为1.4%。与阿莫西林、克拉霉素和甲硝唑相比，氟喹诺酮类药物的耐药率最低。