von Sydow M, Sönnerborg A, Gaines H, Strannegård O
Department of Virology, Central Microbiological Laboratory, Stockholm County Council, Sweden.
AIDS Res Hum Retroviruses. 1991 Apr;7(4):375-80. doi: 10.1089/aid.1991.7.375.
Serum samples of 120 patients in different stages of chronic human immunodeficiency virus type 1 (HIV-1) infection, 11 patients with primary HIV-1 infection (PHI), and 49 HIV-1 seronegative homosexual men were analyzed for tumor necrosis factor-alpha (TNF-alpha), interferon-alpha (IFN-alpha), and HIV-1 p24 antigen. Increased levels of IFN-alpha and TNF-alpha were found in some, but not all, cases with PHI. During progressing disease IFN-alpha occurred in serum with increasing frequency and concentration. Raised levels of TNF-alpha were found in all stages of chronic infection, but were less common in patients with AIDS than were raised levels of IFN-alpha. The levels of the two substances were not correlated. There was a correlation between IFN-alpha, but not TNF-alpha, and the occurrence of HIV-1 p24 antigen in serum. These results suggest that IFN-alpha and TNF-alpha are induced by different agents during HIV-1 infection. The findings would be consistent with the hypothesis that IFN-alpha and TNF-alpha are counteracting forces that have important down- and upregulatory effects, respectively, on HIV-1 replication in vivo.
对120例处于不同阶段的慢性1型人类免疫缺陷病毒（HIV-1）感染者、11例原发性HIV-1感染（PHI）患者以及49例HIV-1血清阴性同性恋男性的血清样本进行了肿瘤坏死因子-α（TNF-α）、干扰素-α（IFN-α）和HIV-1 p24抗原分析。在部分（但并非全部）PHI病例中发现IFN-α和TNF-α水平升高。在疾病进展过程中，血清中IFN-α出现的频率和浓度不断增加。在慢性感染的各个阶段均发现TNF-α水平升高，但在艾滋病患者中，TNF-α水平升高的情况不如IFN-α常见。这两种物质的水平不相关。血清中IFN-α与HIV-1 p24抗原的出现存在相关性，而TNF-α与HIV-1 p24抗原的出现无相关性。这些结果表明，在HIV-1感染期间，IFN-α和TNF-α由不同的因子诱导产生。这些发现与以下假设一致，即IFN-α和TNF-α是相互拮抗的力量，分别对体内HIV-1复制具有重要的下调和上调作用。
