Zurier R B, Doty J, Goldenberg A
Prostaglandins. 1977 Jan;13(1):25-31. doi: 10.1016/0090-6980(77)90039-9.
The cyclic AMP response to prostaglandin E1 (PGE1) was studied in peripheral blood (PB) and synovial fluid (SF) mononuclear cells from patients with rheumatoid arthritis (RA). The PGE1 induced accumulation of cyclic AMP was consistently (7 of 8 patients) less in cell suspensions derived from SF than in suspensions of equivalent numbers of mononuclear cells obtained simultaneously from PB. The high PB/SF cyclic AMP ratio was seen most clearly at the lowest concentration (10(-6)M) of PGE1 tested. There was no correlation between the patients' therapy and cyclic AMP response to PGE1. The high PB/SF cyclic AMP ratio was not accounted for by the presence of platelets in PB cell suspensions.
对类风湿性关节炎（RA）患者外周血（PB）和滑液（SF）中的单核细胞进行了研究，观察其对前列腺素E1（PGE1）的环磷酸腺苷（cAMP）反应。PGE1诱导的cAMP积累在来自SF的细胞悬液中始终（8例患者中的7例）低于同时从PB获得的等量单核细胞悬液。在测试的最低PGE1浓度（10^(-6)M）下，PB/SF的cAMP高比率最为明显。患者的治疗与对PGE1的cAMP反应之间没有相关性。PB细胞悬液中血小板的存在并不能解释PB/SF的cAMP高比率。
