• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与塞伦盖蒂狮子对布氏锥虫获得性免疫一致的年龄血清阳性模式。

Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions.

机构信息

Centre for Infectious Disease, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom.

出版信息

PLoS Negl Trop Dis. 2008;2(12):e347. doi: 10.1371/journal.pntd.0000347. Epub 2008 Dec 9.

DOI:10.1371/journal.pntd.0000347
PMID:19065258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2586656/
Abstract

Trypanosomes cause disease in humans and livestock throughout sub-Saharan Africa. Although various species show evidence of clinical tolerance to trypanosomes, until now there has been no evidence of acquired immunity to natural infections. We discovered a distinct peak and decrease in age prevalence of T. brucei s.l. infection in wild African lions that is consistent with being driven by an exposure-dependent increase in cross-immunity following infections with the more genetically diverse species, T. congolense sensu latu. The causative agent of human sleeping sickness, T. brucei rhodesiense, disappears by 6 years of age apparently in response to cross-immunity from other trypanosomes, including the non-pathogenic subspecies, T. brucei brucei. These findings may suggest novel pathways for vaccinations against trypanosomiasis despite the notoriously complex antigenic surface proteins in these parasites.

摘要

锥虫会在整个撒哈拉以南非洲地区的人类和家畜中引发疾病。尽管各种物种都表现出对锥虫具有临床耐受性的证据，但直到现在，还没有对自然感染产生获得性免疫的证据。我们在野生非洲狮中发现了一种明显的、与年龄相关的 T. brucei s.l.感染率的峰值和下降，这与在感染了遗传上更为多样化的物种 T. congolense sensu latu 后，依赖于暴露的交叉免疫的增加相一致。导致人类昏睡病的病原体 T. brucei rhodesiense 在 6 岁时就明显消失，显然是由于来自其他锥虫的交叉免疫，包括非致病性亚种 T. brucei brucei。尽管这些寄生虫的抗原表面蛋白非常复杂，但这些发现可能为锥虫病疫苗接种提供了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd78/2586656/8606cebecf09/pntd.0000347.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd78/2586656/05787eaf57d3/pntd.0000347.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd78/2586656/c1bf10ce617d/pntd.0000347.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd78/2586656/8606cebecf09/pntd.0000347.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd78/2586656/05787eaf57d3/pntd.0000347.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd78/2586656/c1bf10ce617d/pntd.0000347.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd78/2586656/8606cebecf09/pntd.0000347.g003.jpg

相似文献

1
Patterns in age-seroprevalence consistent with acquired immunity against Trypanosoma brucei in Serengeti lions.与塞伦盖蒂狮子对布氏锥虫获得性免疫一致的年龄血清阳性模式。
PLoS Negl Trop Dis. 2008;2(12):e347. doi: 10.1371/journal.pntd.0000347. Epub 2008 Dec 9.
2
Study on the sequential tsetse-transmitted Trypanosoma congolense, T. brucei brucei and T. vivax infections to African buffalo, eland, waterbuck, N'Dama and Boran cattle.关于采采蝇传播的刚果锥虫、布氏布氏锥虫和活泼锥虫对非洲水牛、大羚羊、水羚、恩达马牛和博拉安牛的序贯感染研究。
Vet Parasitol. 1999 Jan 14;80(3):197-213. doi: 10.1016/s0304-4017(98)00209-x.
3
Spatial distribution and trypanosome infection of tsetse flies in the sleeping sickness focus of Zimbabwe in Hurungwe District.津巴布韦胡伦圭区昏睡病疫源地采采蝇的空间分布及锥虫感染情况
Parasit Vectors. 2016 Nov 25;9(1):605. doi: 10.1186/s13071-016-1879-5.
4
African trypanosomes.非洲锥虫。
Parasit Vectors. 2019 Apr 29;12(1):190. doi: 10.1186/s13071-019-3355-5.
5
Detection and identification of pathogenic trypanosome species in tsetse flies along the Comoé River in Côte d'Ivoire.在科特迪瓦的科莫埃河沿岸采采蝇中致病锥虫种类的检测与鉴定。
Parasite. 2015;22:18. doi: 10.1051/parasite/2015018. Epub 2015 Jun 2.
6
Evaluating the impact of targeting livestock for the prevention of human and animal trypanosomiasis, at village level, in districts newly affected with T. b. rhodesiense in Uganda.在乌干达新受罗德西亚布氏锥虫感染的地区，于村庄层面评估以牲畜为目标预防人类和动物锥虫病的影响。
Infect Dis Poverty. 2017 Feb 6;6(1):16. doi: 10.1186/s40249-016-0224-8.
7
The use of molecular technology to investigate trypanosome infections in tsetse flies at Liwonde Wild Life Reserve.利用分子技术调查利翁德野生动物保护区采采蝇中的锥虫感染情况。
Malawi Med J. 2019 Dec;31(4):233-237. doi: 10.4314/mmj.v31i4.3.
8
Molecular prevalence of trypanosome infections in cattle and tsetse flies in the Maasai Steppe, northern Tanzania.坦桑尼亚北部马赛草原牛和采采蝇锥体虫感染的分子流行率。
Parasit Vectors. 2017 Oct 23;10(1):507. doi: 10.1186/s13071-017-2411-2.
9
Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria.尼日利亚北部采采蝇体内不同锥虫种类及亚种的分子鉴定
Parasit Vectors. 2016 May 23;9(1):301. doi: 10.1186/s13071-016-1585-3.
10
Polymerase chain reaction identification of in wild tsetse flies from Nkhotakota Wildlife Reserve, Malawi.在马拉维恩科塔科塔野生动物保护区的野生采采蝇中进行聚合酶链反应鉴定。
Malawi Med J. 2017 Mar;29(1):5-9.

引用本文的文献

1
Comparative evaluation of rapid diagnostic test and PCR-based diagnostic assay for identification of trypanosomes in cattle of Apac and Kiryandongo districts, Uganda: A cross sectional study.乌干达阿帕克和基延东戈地区牛锥虫鉴定的快速诊断测试与基于聚合酶链反应的诊断检测方法的比较评估：一项横断面研究
BMC Vet Res. 2024 Dec 19;20(1):570. doi: 10.1186/s12917-024-04436-7.
2
Decoding the impact of nuclear organization on antigenic variation in parasites.解码核组织对寄生虫抗原变异的影响。
Nat Microbiol. 2023 Aug;8(8):1408-1418. doi: 10.1038/s41564-023-01424-9. Epub 2023 Jul 31.
3
Prevalence and risk factors for trypanosome infection in cattle from communities surrounding the Murchison Falls National Park, Uganda.

本文引用的文献

1
Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific.布氏锥虫的变异表面糖蛋白基因库已经分化，变得具有菌株特异性。
BMC Genomics. 2007 Jul 13;8:234. doi: 10.1186/1471-2164-8-234.
2
African trypanosomiasis.非洲锥虫病
Ann Trop Med Parasitol. 2006 Dec;100(8):679-701. doi: 10.1179/136485906X112211.
3
Sleeping sickness in Uganda: a thin line between two fatal diseases.乌干达的昏睡病：两种致命疾病之间的细微界限。
乌干达姆奇森瀑布国家公园周边社区牛群锥虫感染的流行情况及危险因素。
Parasit Vectors. 2021 Oct 7;14(1):513. doi: 10.1186/s13071-021-04987-w.
4
Epidemiology of Trypanosomiasis in Wildlife-Implications for Humans at the Wildlife Interface in Africa.野生动物中锥虫病的流行病学——对非洲野生动物与人类交界地区人类的影响
Front Vet Sci. 2021 Jun 14;8:621699. doi: 10.3389/fvets.2021.621699. eCollection 2021.
5
A serological survey of brucellosis in wildlife in four major National Parks of Uganda.乌干达四个主要国家公园野生动物布鲁氏菌病的血清学调查。
BMC Vet Res. 2021 Mar 1;17(1):95. doi: 10.1186/s12917-021-02782-4.
6
Evaluating the impact of targeting livestock for the prevention of human and animal trypanosomiasis, at village level, in districts newly affected with T. b. rhodesiense in Uganda.在乌干达新受罗德西亚布氏锥虫感染的地区，于村庄层面评估以牲畜为目标预防人类和动物锥虫病的影响。
Infect Dis Poverty. 2017 Feb 6;6(1):16. doi: 10.1186/s40249-016-0224-8.
7
Quantifying Heterogeneity in Host-Vector Contact: Tsetse (Glossina swynnertoni and G. pallidipes) Host Choice in Serengeti National Park, Tanzania.量化宿主-媒介接触中的异质性：坦桑尼亚塞伦盖蒂国家公园采采蝇（斯氏舌蝇和淡黄舌蝇）的宿主选择
PLoS One. 2016 Oct 5;11(10):e0161291. doi: 10.1371/journal.pone.0161291. eCollection 2016.
8
Studies of trypanosomiasis in the Luangwa valley, north-eastern Zambia.赞比亚东北部卢安瓜河谷的锥虫病研究。
Parasit Vectors. 2015 Sep 30;8:497. doi: 10.1186/s13071-015-1112-y.
9
Domestic pigs as potential reservoirs of human and animal trypanosomiasis in Northern Tanzania.坦桑尼亚北部的家猪可能成为人类和动物锥虫病的宿主。
Parasit Vectors. 2013 Nov 9;6(1):322. doi: 10.1186/1756-3305-6-322.
10
Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania.利用分子数据进行流行病学推断：评估坦桑尼亚塞伦盖蒂地区采采蝇中罗得西亚锥虫的流行率。
PLoS Negl Trop Dis. 2012 Jan;6(1):e1501. doi: 10.1371/journal.pntd.0001501. Epub 2012 Jan 31.
BMJ. 2005 Nov 26;331(7527):1238-41. doi: 10.1136/bmj.331.7527.1238.
4
A PCR based assay for detection and differentiation of African trypanosome species in blood.一种基于聚合酶链反应的检测和区分血液中非洲锥虫种类的检测方法。
Exp Parasitol. 2005 Sep;111(1):24-9. doi: 10.1016/j.exppara.2005.03.014.
5
The genome of the African trypanosome Trypanosoma brucei.非洲锥虫布氏锥虫的基因组。
Science. 2005 Jul 15;309(5733):416-22. doi: 10.1126/science.1112642.
6
Probabilistic order in antigenic variation of Trypanosoma brucei.布氏锥虫抗原变异中的概率顺序
Int J Parasitol. 2005 Aug;35(9):961-72. doi: 10.1016/j.ijpara.2005.05.004.
7
Ecological change, group territoriality, and population dynamics in Serengeti lions.塞伦盖蒂狮群的生态变化、群体领地行为与种群动态
Science. 2005 Jan 21;307(5708):390-3. doi: 10.1126/science.1105122.
8
Maximum likelihood for parasitologists.寄生虫学家的最大似然法。
Parasitol Today. 1994 Dec;10(12):489-93. doi: 10.1016/0169-4758(94)90163-5.
9
Are fitness costs associated with resistance to human serum in Trypanosoma brucei rhodesiense?
Trends Parasitol. 2004 Jul;20(7):311-5. doi: 10.1016/j.pt.2004.04.015.
10
Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle.在耐西非N'Dama牛和易感东非博拉牛的杂交后代中，对控制锥虫耐受量的数量性状基因座进行定位。
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7443-8. doi: 10.1073/pnas.1232392100. Epub 2003 Jun 12.