Hindersin S, Mönnighoff I, Schipper J, Hoffmann T K
Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Düsseldorf.
Laryngorhinootologie. 2009 Feb;88(2):112-5. doi: 10.1055/s-0028-1100387. Epub 2008 Dec 8.
In addition to mucosal manifestation in the gastrointestinal tract metastatic Crohn's disease also involves cutaneous sites. We report on a 33 year-old female suffering from diarrhea, aphthous ulceration and recurrent granulomatous abscesses on different cutaneous sites also involving the head neck region. Besides a general infection constellation, histologic examination of affected skin and mucosa revealed ulceration with chronic-granulomatous inflammation with Langerhans giant cells. Taking together the intestinal and cutaneous lesions and their histologic appearance as well as the clinical features lead to metastatic Crohn's disease. The patient recovered under immunosuppressive drugs. Metastastic Crohn's disease is a rare and severe form of the well known autoimmune disease which needs interdisciplinary diagnostic and therapy.
除了胃肠道的黏膜表现外，转移性克罗恩病还累及皮肤部位。我们报告了一名33岁女性，患有腹泻、口疮性溃疡以及不同皮肤部位（包括头颈部区域）反复出现的肉芽肿性脓肿。除了一般的感染症状外，对受累皮肤和黏膜的组织学检查显示有溃疡，伴有慢性肉芽肿性炎症及朗汉斯巨细胞。综合肠道和皮肤病变、其组织学表现以及临床特征，诊断为转移性克罗恩病。该患者在免疫抑制药物治疗下康复。转移性克罗恩病是一种罕见且严重的著名自身免疫性疾病，需要多学科的诊断和治疗。
