化脓性汗腺炎（反向性痤疮）的合并症。
Comorbidities of hidradenitis suppurativa (acne inversa).
作者信息
Fimmel Sabine, Zouboulis Christos C
机构信息
Laboratory for Biogerontology; Dermato-Pharmacology and Dermato-Endocrinology; Institute of Clinical Pharmacology and Toxicology; Campus Benjamin Franklin; Charité Universitaetsmedizin Berlin, Germany.
出版信息
Dermatoendocrinol. 2010 Jan;2(1):9-16. doi: 10.4161/derm.2.1.12490.
Abstract
Comorbidities of hidradenitis suppurativa (acne inversa) were reviewed by extracting original and review publications included in MEDLINE, EMBASE and COCHRANE libraries using the terms "hidradenitis," "Verneuil" and "acne inversa." Follicular occlusion disorders, inflammatory bowel diseases, especially Crohn disease, spondylarthropathy, other hyperergic diseases, genetic keratin disorders associated with follicular occlusion and squamous cell carcinoma were the most common hidradenitis suppurativa comorbid diseases. A first classification of these major comorbidities and their possible genetic background reveals a list of chromosome loci and genes, which could be hidradenitis suppurativa candidates. Most of these diseases belong to the group of autoinflammatory disorders, where th17 cell cytokines seem to play a central role.
摘要
通过检索MEDLINE、EMBASE和COCHRANE数据库中使用“化脓性汗腺炎”“韦尔诺伊病”和“反向痤疮”等术语的原始文献和综述文献，对化脓性汗腺炎（反向痤疮）的合并症进行了回顾。毛囊闭锁三联征、炎症性肠病，尤其是克罗恩病、脊柱关节病、其他超敏性疾病、与毛囊闭锁相关的遗传性角蛋白疾病以及鳞状细胞癌是化脓性汗腺炎最常见的合并疾病。对这些主要合并症及其可能的遗传背景进行的首次分类揭示了一系列染色体位点和基因，它们可能是化脓性汗腺炎的候选因素。这些疾病大多属于自身炎症性疾病组，其中th17细胞细胞因子似乎起着核心作用。
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Interobserver variability of clinical scores in hidradenitis suppurativa is low.在化脓性汗腺炎中，临床评分的观察者间变异性较低。
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