用蛋白酶探针评估三氟甲基的生物电子等排性。 - Suppr

Assessing the bioisosterism of the trifluoromethyl group with a protease probe.

作者信息

Jagodzinska Monika, Huguenot Florent, Candiani Gabriele, Zanda Matteo

机构信息

Dipartimento di Chimica, Materiali ed Ingegneria Chimica G. Natta, Politecnico di Milano via Mancinelli 7, 20131 Milano, Italy.

出版信息

ChemMedChem. 2009 Jan;4(1):49-51. doi: 10.1002/cmdc.200800321.

DOI:10.1002/cmdc.200800321

PMID:19065645

Abstract

摘要

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Assessing the bioisosterism of the trifluoromethyl group with a protease probe.用蛋白酶探针评估三氟甲基的生物电子等排性。

ChemMedChem. 2009 Jan;4(1):49-51. doi: 10.1002/cmdc.200800321.

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C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging.C-5-二取代巴比妥酸盐作为用于无创基质金属蛋白酶成像的潜在分子探针。

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Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity.将4-(4-溴苯基)苯磺酰基引入伊洛马司他的酰肼类似物中可得到具有更高选择性的强效明胶酶B（基质金属蛋白酶-9）抑制剂。

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Assessing the bioisosterism of the trifluoromethyl group with a protease probe.

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