Goldstein Byron, Coombs Daniel, Faeder James R, Hlavacek William S
Theoretical Biology and Biophysics Group, T-10 MS K710, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 875435, USA.
Adv Exp Med Biol. 2008;640:82-94. doi: 10.1007/978-0-387-09789-3_8.
Kinetic proofreading is an intrinsic property of the cell signaling process. It arises as a consequence of the multiple interactions that occur after a ligand triggers a receptor to initiate a ignaling cascade and it ensures that false signals do not propagate to completion. In order for an active signaling complex to form after a ligand binds to a cell surface receptor, a sequence of binding and phosphorylation events must occur that are rapidly reversed if the ligand dissociates from the receptor. This gives rise to a mechanism by which cells can discriminate among ligands that bind to the same receptor but form ligand-receptor complexes with different lifetimes. We review experiments designed to test for kinetic proofreading and models that exhibit kinetic proofreading.
动力学校对是细胞信号传导过程的一种内在特性。它是配体触发受体启动信号级联反应后发生的多种相互作用的结果，可确保错误信号不会传播至完成。为了在配体与细胞表面受体结合后形成活性信号复合物，必须发生一系列结合和磷酸化事件，若配体从受体上解离，这些事件会迅速逆转。这产生了一种机制，通过该机制细胞可以区分与同一受体结合但形成具有不同寿命的配体 - 受体复合物的配体。我们回顾了旨在测试动力学校对的实验以及表现出动力学校对的模型。
