[马钱子碱隐形脂质体的药学特性]
[Pharmaceutical characteristics of brucine stealth liposomes].
作者信息
Chen Jun, Wang Wei, Cai Bao-chang, Hu Wei, Wang Li-jie
机构信息
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2100-4.
OBJECTIVE
To prepare brucine stealth liposomes and compare the in vitro characteristics with brucine conventional liposomes.
METHOD
Brucine stealth liposomes and conventional liposomes were both prepared by ammonium sulfate transmembrane gradients. The encapsulation efficiency, particle size, in vitro release profiles and stability were compared respectively.
RESULT
The encapsulation efficiency of brucine stealth liposomes and conventional liposomes were (80.7 +/- 0.5)%, and (80.5 +/- 0.3)%, respectively. The mean paricle sizes were 103.5 nm and 169. 4 nm, respectively. Whether rat plasma was added or not, the release rate and degree of brucine stealth liposomes were significantly lower than those of conventional liposomes. Brucine stealth liposomes were more stable than conventional liposomes.
CONCLUSION
As the antitumor durg delivery system, the in vitro characteristics of brucine stealth liposomes are more satisfactory than the corresponding conventional liposomes.
目的
制备马钱子碱隐形脂质体，并与马钱子碱普通脂质体的体外特性进行比较。
方法
采用硫酸铵跨膜梯度法制备马钱子碱隐形脂质体和普通脂质体。分别比较两者的包封率、粒径、体外释放曲线及稳定性。
结果
马钱子碱隐形脂质体和普通脂质体的包封率分别为（80.7±0.5）%和（80.5±0.3）%。平均粒径分别为103.5nm和169.4nm。无论是否添加大鼠血浆，马钱子碱隐形脂质体的释放速率和释放程度均显著低于普通脂质体。马钱子碱隐形脂质体比普通脂质体更稳定。
结论
作为抗肿瘤药物递送系统，马钱子碱隐形脂质体的体外特性比相应的普通脂质体更令人满意。
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