褪黑素对大鼠脑出血后的长期影响。
Long-term effects of melatonin after intracerebral hemorrhage in rats.
作者信息
Hartman R E, Rojas H A, Lekic T, Ayer R, Lee S, Jadhav V, Titova E, Tang J, Zhang J H
机构信息
Department of Psychology, Loma Linda University, 11130 Anderson St. 119, Loma Linda, CA 92354, USA.
出版信息
Acta Neurochir Suppl. 2008;105:99-100. doi: 10.1007/978-3-211-09469-3_20.
Free radical scavengers have been shown to improve short-term outcome after intracerebral hemorrhage (ICH). The purpose of this study was to evaluate whether melatonin (a potent free radical scavenger and an indirect antioxidant) can improve short- and/or long-term neurological function after ICH, which was induced by collagenase injection into the striatum of adult rats. Melatonin (15 mg/kg) was administered by intraperitoneal injection at 1, 24, 48, and 72 h. Neurological and behavioral testing was performed at several time points from 1 day to 8 weeks post-ICH. Neurological and behavioral deficits were observed in ICH rats at all time points, but the melatonin treatment regimen did not improve performance or level of brain injury.
自由基清除剂已被证明可改善脑出血（ICH）后的短期预后。本研究的目的是评估褪黑素（一种有效的自由基清除剂和间接抗氧化剂）是否能改善成年大鼠纹状体内注射胶原酶诱导脑出血后的短期和/或长期神经功能。在1、24、48和72小时通过腹腔注射给予褪黑素（15毫克/千克）。在脑出血后1天至8周的多个时间点进行神经和行为测试。在所有时间点的脑出血大鼠中均观察到神经和行为缺陷，但褪黑素治疗方案并未改善其表现或脑损伤程度。
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