Treatment of light chain deposition disease with bortezomib and dexamethasone.
作者信息
Kastritis Efstathios, Migkou Magdalini, Gavriatopoulou Maria, Zirogiannis Panos, Hadjikonstantinou Valsamakis, Dimopoulos Meletios A
出版信息
Haematologica. 2009 Feb;94(2):300-2. doi: 10.3324/haematol.13548. Epub 2008 Dec 9.
Abstract
摘要
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Haematologica. 2007 Oct;92(10):1351-8. doi: 10.3324/haematol.11325.
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Reversal of acute renal failure by bortezomib-based chemotherapy in patients with multiple myeloma.硼替佐米为主的化疗对多发性骨髓瘤患者急性肾衰竭的逆转作用
Haematologica. 2007 Oct;92(10):1411-4. doi: 10.3324/haematol.11463.
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Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.
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Blood. 2007 Mar 15;109(6):2604-6. doi: 10.1182/blood-2006-09-046409. Epub 2006 Nov 30.
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The mesangium as a target for glomerulopathic light and heavy chains: pathogenic considerations in light and heavy chain-mediated glomerular damage.系膜作为肾小球病性轻链和重链的靶标：轻链和重链介导的肾小球损伤的发病机制探讨
Contrib Nephrol. 2007;153:116-34. doi: 10.1159/000096764.
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Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.蛋白酶体阻断通过协同下调I型胶原蛋白和金属蛋白酶组织抑制剂-1，并上调人皮肤成纤维细胞中金属蛋白酶-1的产生，发挥抗纤维化活性。
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