内淋巴囊渗透压反应性阳离子通道TRPV4的表达

Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac.

作者信息

Kumagami H, Terakado M, Sainoo Y, Baba A, Fujiyama D, Fukuda T, Takasaki K, Takahashi H

机构信息

Department of Otolaryngology, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8501, Japan.

出版信息

Audiol Neurootol. 2009;14(3):190-7. doi: 10.1159/000180290. Epub 2008 Dec 10.

DOI:10.1159/000180290

PMID:19066426

Abstract

The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac.

摘要

研究了瞬时受体电位香草酸亚型4（TRPV4）在内淋巴囊中的免疫组化表达模式及其生理作用。TRPV4主要表达于富含线粒体的细胞的顶端膜，并且在大鼠内淋巴囊的组织培养中观察到TRPV4对细胞体积的调节作用。TRPV4也存在于前庭神经鞘瘤患者和梅尼埃病患者的内淋巴囊中。TRPV4被认为在人类内淋巴囊的细胞和液体体积调节中作为一种渗透压感受器发挥作用。