Bille A, Olafsson K, Jensen H V, Andersen J
Psychogeriatric Department, Vordingborg Psychiatric Hospital, Denmark.
Acta Psychiatr Scand. 1991 May;83(5):321-3. doi: 10.1111/j.1600-0447.1991.tb05548.x.
The serum prolactin (PRL) responses to stimulation with thyrotropin-releasing hormone (TRH) (500 micrograms Protirelin) were compared in 14 patients with multi-infarct dementia (MID) and 10 patients with senile dementia of the Alzheimer type (SDAT). Between the MID and the SDAT patients, there were no statistically significant differences in the median serum PRL concentrations, median changes in serum PRL concentrations or median proportional changes in serum PRL concentrations. Further, the serum PRL responses did not correlate with the GBS scale scores (degrees of dementia) or the GBS subscale scores (clinical profiles, including motor functioning, emotional functioning and intellectual functioning). In conclusion, the study does not support the hypothesis that serum PRL responses to TRH stimulation are of diagnostic value in differentiating between MID and SDAT.
对14例多发梗死性痴呆（MID）患者和10例阿尔茨海默型老年性痴呆（SDAT）患者，比较了血清催乳素（PRL）对促甲状腺激素释放激素（TRH）（500微克普罗瑞林）刺激的反应。在MID患者和SDAT患者之间，血清PRL浓度中位数、血清PRL浓度变化中位数或血清PRL浓度比例变化中位数均无统计学显著差异。此外，血清PRL反应与GBS量表评分（痴呆程度）或GBS分量表评分（临床概况，包括运动功能、情感功能和智力功能）无关。总之，该研究不支持血清PRL对TRH刺激的反应在鉴别MID和SDAT方面具有诊断价值这一假说。
