Dysken M W, Falk A, Pew B, Kuskowski M, Krahn D D
Geriatric Research, Education, and Clinical Center, Minneapolis VA Medical Center, MN 55417.
Biol Psychiatry. 1990 Jul 15;28(2):144-50. doi: 10.1016/0006-3223(90)90631-b.
We performed thyrotropin-releasing hormone (TRH) stimulation testing in 18 nondepressed patients with primary degenerative dementia (10 M, 8F; average age +/- SD = 68 +/- 7) and 12 elderly controls (7M, 5F; average age +/- SD = 61 +/- 6). Six patients were retested approximately 2 years later. Initial Mini-Mental State Examination scores for patients ranged from 2 to 28 (average +/- SD = 18 +/- 6) and the scores for the control subjects were all equal to 30. Protirelin (500 micrograms) was injected iv and blood was sampled at 0, 15, 30, 45, 60, and 90 min for thyrotropin-stimulating hormone (TSH) and prolactin (PRL). There were no significant differences between patients and controls in baseline T4, T3 uptake, TSH, or PRL. No significant differences were found between patients and controls for either TRH-stimulated TSH or PRL at all time points. Duration of illness, severity of dementia, and severity of depressive symptoms did not correlate significantly with stimulation test results. There were, however, significantly greater responses in stimulated TSH and PRL for women compared with men in both patients and controls. Upon repeat testing (n = 6), TRH-stimulated TSH and PRL were not significantly different from the initial results.
我们对18例非抑郁的原发性退行性痴呆患者（10例男性，8例女性；平均年龄±标准差=68±7岁）和12例老年对照者（7例男性，5例女性；平均年龄±标准差=61±6岁）进行了促甲状腺激素释放激素（TRH）刺激试验。约2年后对6例患者进行了重新测试。患者最初的简易精神状态检查表评分范围为2至28分（平均±标准差=18±6），对照者的评分均为30分。静脉注射普罗瑞林（500微克），并在0、15、30、45、60和90分钟采集血样，检测促甲状腺激素（TSH）和催乳素（PRL）。患者和对照者在基线T4、T3摄取、TSH或PRL方面无显著差异。在所有时间点，患者和对照者在TRH刺激后的TSH或PRL方面均未发现显著差异。病程、痴呆严重程度和抑郁症状严重程度与刺激试验结果无显著相关性。然而，在患者和对照者中，女性刺激后的TSH和PRL反应均显著大于男性。在重复测试（n = 6）时，TRH刺激后的TSH和PRL与初始结果无显著差异。
