Branco Bernardino C, Sachar David B, Heimann Tomas M, Sarpel Umut, Harpaz Noam, Greenstein Adrian J
Department of General Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA.
Inflamm Bowel Dis. 2009 Feb;15(2):295-9. doi: 10.1002/ibd.20609.
The occurrence of adenocarcinoma following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is an infrequent and but potentially lethal complication. We have seen 1 such case among 520 IPAAs performed in our group practice between 1978 and February 2008. We have added this case to a review of 25 previously reported cases of adenocarcinoma of the pouch or outflow tract following IPAA for UC. Our conclusions are 1) that post-IPAA cancer can occur following either mucosectomy or stapled anastomosis; 2) that this malignancy can occur after IPAA performed for UC either with or without neoplasia; and 3) that this complication is seen whether or not the initial cancer or dysplasia had involved the rectum.
溃疡性结肠炎（UC）患者行回肠储袋肛管吻合术（IPAA）后发生腺癌是一种罕见但可能致命的并发症。1978年至2008年2月间，我们团队共进行了520例IPAA手术，其中出现了1例这种情况。我们将该病例纳入了对先前报道的25例UC患者IPAA术后储袋或流出道腺癌病例的回顾中。我们的结论是：1）IPAA术后癌症可发生于黏膜切除术或吻合器吻合术后；2）无论有无肿瘤形成，UC患者行IPAA术后均可发生这种恶性肿瘤；3）无论最初的癌症或发育异常是否累及直肠，均可出现这种并发症。
