硼酸酯与锂化环氧化合物的同系化反应用于立体控制合成1,2 - 二醇、1,3 - 二醇和1,2,4 - 三醇。
Homologation of boronic esters with lithiated epoxides for the stereocontrolled synthesis of 1,2- and 1,3-diols and 1,2,4-triols.
作者信息
Vedrenne Emeline, Wallner Olov A, Vitale Maxime, Schmidt Frank, Aggarwal Varinder K
机构信息
School of Chemistry, University of Bristol, Bristol BS81TS, UK.
出版信息
Org Lett. 2009 Jan 1;11(1):165-8. doi: 10.1021/ol802651b.
PMID:19067552
Abstract
Lithiated epoxides react stereospecifically with boronic esters to give syn-1,2-diols, a process that can be used iteratively to create triols containing four stereogenic centers.
摘要
锂化环氧化合物与硼酸酯发生立体专一性反应生成顺式-1,2-二醇，该过程可反复用于合成含有四个手性中心的三醇。
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