Smith R P, Chalmers R M, Elwin K, Clifton-Hadley F A, Mueller-Doblies D, Watkins J, Paiba G A, Giles M
Centre for Epidemiology and Risk Analysis Department, Veterinary Laboratories Agency (VLA), New Haw, Addlestone, Surrey, United Kingdom.
Zoonoses Public Health. 2009 Feb;56(1):24-33. doi: 10.1111/j.1863-2378.2008.01178.x. Epub 2008 Nov 21.
Companion animals owned by human patients with cryptosporidiosis (cases) and those animals owned by the wider human population (controls), were studied to determine whether Cryptosporidium was more likely to be excreted by case animals than controls. A total of 280 recently voided faecal samples (114 case animals and 166 control animals) were collected and tested by immunomagnetic separation and immunofluorescent microscopy. A multivariable model was also created to identify pet characteristics, contacts and management factors associated with Cryptosporidium infection in animals, using information collected by a standardized questionnaire. The model was designed to take into account the clustering of samples at the owner level and whether the sampled animal was a case or control.
对隐孢子虫病人类患者（病例组）所拥有的伴侣动物以及更广泛人群（对照组）所拥有的动物进行了研究，以确定病例组动物排出隐孢子虫的可能性是否高于对照组。总共收集了280份近期排出的粪便样本（114份病例组动物样本和166份对照组动物样本），并通过免疫磁珠分离和免疫荧光显微镜进行检测。还使用标准化问卷收集的信息创建了一个多变量模型，以识别与动物隐孢子虫感染相关的宠物特征、接触情况和管理因素。该模型旨在考虑主人层面样本的聚集情况以及采样动物是病例组还是对照组。
