Cardoso Armando, Carvalho Liliana S, Lukoyanova Elena A, Lukoyanov Nikolai V
Faculty of Medicine of Porto, Institute of Anatomy, Alameda Prof Hernâni Monteiro, Porto, Portugal.
Epilepsy Behav. 2009 Feb;14(2):293-9. doi: 10.1016/j.yebeh.2008.11.004. Epub 2008 Dec 7.
Affective symptoms are frequently observed in patients with epilepsy. Although the etiology of these behavioral complications remains unknown, it is possible that brain damage associated with frequent or prolonged seizures may contribute to their development. To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine. Using the open-field and elevated plus-maze tests, we detected the presence of behavioral alterations indicative of elevated levels of anxiety in rats that were administered a course of ECS seizures. Fear conditioning was also enhanced in these animals. However, the rats that had experienced SE exhibited less anxiety-like behavior than controls and were severely impaired in fear conditioning. These results support the notion that brain lesions caused by either brief repeated seizures or SE is sufficient to induce some affective disturbances.
情感症状在癫痫患者中经常被观察到。尽管这些行为并发症的病因尚不清楚，但频繁或长时间发作相关的脑损伤可能促使其发展。为了解决这个问题，我们研究了电惊厥休克（ECS）诱发的反复短暂发作的行为后遗症，并将其与毛果芸香碱诱导的长时间癫痫持续状态（SE）所导致的后遗症进行比较。通过旷场试验和高架十字迷宫试验，我们在接受ECS发作疗程的大鼠中检测到表明焦虑水平升高的行为改变。这些动物的恐惧条件反射也增强了。然而，经历过SE的大鼠表现出比对照组更少的焦虑样行为，并且在恐惧条件反射方面严重受损。这些结果支持了这样的观点，即短暂反复发作或SE引起的脑损伤足以诱发一些情感障碍。
