Erdoğan Füsun, Gölgeli Asuman, Küçük Ayşegül, Arman Fehim, Karaman Yahya, Ersoy Ali
Neurology Department, Erciyes University, 38039 Kayseri, Turkey.
Epilepsy Behav. 2005 Jun;6(4):537-42. doi: 10.1016/j.yebeh.2005.03.002. Epub 2005 Apr 26.
Status epilepticus (SE) can be harmful to the developing brain. Our knowledge of the emotional and behavioral consequences of generalized SE in developing animals remains limited. Therefore, we investigated the short- and long-term effects of pentylenetetrazole (PTZ)-induced SE on emotional memory and learning and behavioral parameters in immature rats. SE was induced in 16- to 20-day-old rats (P16-P20) using intraperitoneal injections of PTZ (n=21); control rats received saline (n=10). All animals were tested using an elevated T-maze and open-field test 2, 14, 30, and 180 days after SE, to evaluate emotional memory and learning and behavior. Anxiety levels decreased 2 and 14 days after SE, and conditioned learning of PTZ-treated immature rats was better than that of the control rats. These results indicate that a decreased anxiety level facilitates conditioned learning. Behavioral changes are transient, and no emotional memory or learning deficits occur following PTZ-induced SE in immature rats.
癫痫持续状态（SE）可能会对发育中的大脑造成损害。我们对发育中动物全身性SE的情绪和行为后果的了解仍然有限。因此，我们研究了戊四氮（PTZ）诱导的SE对未成熟大鼠情绪记忆、学习和行为参数的短期和长期影响。通过腹腔注射PTZ对16至20日龄大鼠（P16 - P20）诱导SE（n = 21）；对照大鼠接受生理盐水（n = 10）。在SE后2、14、30和180天，使用高架T迷宫和旷场试验对所有动物进行测试，以评估情绪记忆、学习和行为。SE后2天和14天焦虑水平降低，PTZ处理的未成熟大鼠的条件学习优于对照大鼠。这些结果表明焦虑水平降低有助于条件学习。行为变化是短暂的，PTZ诱导的SE后未成熟大鼠未出现情绪记忆或学习缺陷。
