Plótár Vanda, Szentirmay Zoltán, Orosz Zsolt
Országos Onkológiai Intézet, Daganatpatológiai Osztály, 1122 Budapest Ráth Gy. u. 7-9.
Magy Onkol. 2008 Dec;52(4):363-73. doi: 10.1556/MOnkol.52.2008.4.5.
At the histological examination of an increasing number of melanocytic tumors there is a need to use various immunohistochemical methods. Currently, we are supplied by several antibodies working well on formalin-fixed, paraffin-embedded samples. We have tested five antibodies (S-100, HMB-45, Melan-A, MITF, PNL-2) on 34 benign and 34 malignant melanocytic tumors. We examined the specificity and sensitivity in the junctional and dermal component separately, with special consideration to features disturbing the evaluation (regression, halo-like inflammation, etc.). We have concluded that the histological diagnosis of melanocytic tumors is based on the detailed examination of traditional HE slides and the immunohistochemical methods only confirm or weaken our opinion.
在对越来越多的黑素细胞肿瘤进行组织学检查时，需要使用各种免疫组织化学方法。目前，我们有几种抗体可很好地用于福尔马林固定、石蜡包埋的样本。我们在34例良性和34例恶性黑素细胞肿瘤上测试了五种抗体（S-100、HMB-45、Melan-A、MITF、PNL-2）。我们分别检查了交界区和真皮成分中的特异性和敏感性，并特别考虑了干扰评估的特征（消退、晕状炎症等）。我们得出结论，黑素细胞肿瘤的组织学诊断基于对传统苏木精-伊红染色切片的详细检查，而免疫组织化学方法只是证实或削弱我们的判断。
