Worbe Yulia, Baup Nicolas, Grabli David, Chaigneau Marion, Mounayar Stéphanie, McCairn Kevin, Féger Jean, Tremblay Léon
Institut National de la Santé et de la Recherche Médicale, Unité 679, Paris F-75013, France.
Cereb Cortex. 2009 Aug;19(8):1844-56. doi: 10.1093/cercor/bhn214. Epub 2008 Dec 9.
The current model of basal ganglia organization postulates their functional division into sensorimotor, associative, and limbic territories, implicated, respectively, in motor, cognitive, and motivational aspects of behavior. Based on this model, we previously demonstrated, in the external segment of globus pallidus of monkeys, that the same neuronal dysfunction induced dyskinesia or abnormal behavior depending on the functional territory. To extend these findings, we performed bicuculline microinjections into the different functional territories of the striatum in 6 monkeys. Abnormal movements were observed after microinjections into the posterior putamen, corresponding to the sensorimotor territory, and into the dorsal part of the anterior striatum, corresponding to the associative functional territory. Within the ventral striatum, referred to as the limbic functional territory, we identified 3 subregions corresponding to different types of abnormal behaviors. Simultaneous neuronal recordings performed close to the microinjection sites confirmed that bicuculline produced a focal increase of neuronal activity surrounded by a zone with neuronal hypoactivity. This study provides new evidence for the involvement of specific striatal regions in movement as well as in a large spectrum of behavioral disorders and suggests that local inhibitory dysfunction could be a pathological mechanism of various neurological and psychiatric disorders.
目前的基底神经节组织模型假定其功能分为感觉运动、联合和边缘区域，分别与行为的运动、认知和动机方面相关。基于此模型，我们之前在猴子的苍白球外侧段证明，相同的神经元功能障碍根据功能区域会诱发运动障碍或异常行为。为了扩展这些发现，我们对6只猴子的纹状体不同功能区域进行了荷包牡丹碱微量注射。在向对应感觉运动区域的后壳核以及对应联合功能区域的前纹状体背侧部分进行微量注射后，观察到了异常运动。在被称为边缘功能区域的腹侧纹状体内，我们确定了3个对应不同类型异常行为的子区域。在微量注射部位附近同时进行的神经元记录证实，荷包牡丹碱使神经元活动局部增加，周围伴有神经元活动减退区域。这项研究为特定纹状体区域参与运动以及多种行为障碍提供了新证据，并表明局部抑制功能障碍可能是各种神经和精神疾病的病理机制。
