Centre de Recherche d'Institut du Cerveau et de la Moelle Epiniére-University Pierre and Marie Curie, Inserm UMR_S975, Pitié-Salpêtrière Hospital, Paris, France.
Cereb Cortex. 2011 Dec;21(12):2733-41. doi: 10.1093/cercor/bhr063. Epub 2011 Apr 20.
The striatum has been identified as a new target for therapeutic deep brain stimulation in the treatment of neurological and psychiatric disorders. The nonhuman primate model offers opportunities for detailed mapping of the behavioral effects of stimulation within the striatum. We recently showed that dysfunction in the dorsal and ventral striatum was able to produce a specific pattern of abnormal movements and behavioral states. In the present study, electrical stimulation of monkey striatum evoked abnormal movements and behavioral states depending not only on the location of stimulation sites but also on the parameters of stimulation. Abnormal movements were induced by stimulation of sites in the anterior associative and posterior sensorimotor striatum. Short-train stimulation evoked myoclonic-like movements and long-train stimulation produced sustained dystonic-like and complex abnormal movements. Long-train stimulation of the anterior part of the striatum, corresponding to the associative-limbic territory, induced 3 abnormal behavioral states--hyperactivity, hypoactivity, and stereotyped behaviors. Short-train stimulation was less effective in producing these effects. No significant effects were observed with the continuous mode of stimulation. Our results show that discontinuous long-train stimulation of the anterior associative and limbic parts of the striatum is the most effective mode of stimulation to produce these behavioral states.
纹状体已被确定为治疗神经和精神疾病的深部脑刺激治疗的新靶点。非人类灵长类动物模型为深入研究刺激对纹状体的行为影响提供了机会。我们最近表明，背侧和腹侧纹状体的功能障碍能够产生特定的异常运动和行为状态模式。在本研究中，电刺激猴子纹状体不仅可以根据刺激部位的位置，还可以根据刺激的参数来诱发异常运动和行为状态。刺激前联合感觉运动纹状体的部位可引起异常运动。短程刺激可诱发肌阵挛样运动，而长程刺激则产生持续的肌张力障碍样和复杂的异常运动。刺激纹状体前部，对应于联合边缘区域，可诱导 3 种异常行为状态——多动、少动和刻板行为。短程刺激在产生这些效果方面效果较差。连续刺激模式没有观察到显著效果。我们的结果表明，不连续的长程刺激纹状体的前联合和边缘部分是产生这些行为状态的最有效刺激模式。
