Ohno Naohito
Tokyo University of Pharmacy and Life Sciences.
Nihon Rinsho. 2008 Dec;66(12):2268-72.
Cell wall glycans of fungi/yeasts are reviewed. Fungi/yeasts produce various kinds of polysaccharides. As part of the cell wall they are interlinked with other components forming a huge network. The insolubility and complex with multiple components makes the research very tough. Studies on beta-glucan have been performed from various views, such as chemistry, conformation, solubility, tissue distribution and metabolism, biological activity, clinical application, receptor, biosynthesis, and antibody. Studies on mannan focus on immunotoxicity, such as anaphylactoid reaction and coronary arteritis induction. alpha-glucan, chitin, and capsular polysaccharide were also mentioned in relation to structure and genes. Compared with human and animal polysaccharides, fungi/yeasts polysaccharides have very characteristic properties.
对真菌/酵母的细胞壁聚糖进行了综述。真菌/酵母产生各种多糖。作为细胞壁的一部分,它们与其他成分相互连接,形成一个巨大的网络。其不溶性以及与多种成分的复杂性使得研究非常困难。已从化学、构象、溶解性、组织分布与代谢、生物活性、临床应用、受体、生物合成和抗体等各种角度对β-葡聚糖进行了研究。对甘露聚糖的研究集中在免疫毒性方面,如类过敏反应和诱导冠状动脉炎。还提到了α-葡聚糖、几丁质和荚膜多糖的结构与基因。与人和动物的多糖相比,真菌/酵母多糖具有非常独特的性质。