Shimosegawa Tooru
Division of Gastroenterology, Tohoku University Graduate School of Medicine.
Nihon Rinsho. 2008 Dec;66(12):2393-406.
Autoimmune pancreatitis (AIP) is a disease which is considered to develop on the background of autoimmune mechanism. It is characterized by unique findings in imagings, appearance of various autoantibodies and elevation of IgG and IgG4 in the blood, and pathologically by lymphoplasmacytic sclerosing pancreatitis (LPSP). It associates various extrapancreatic lesions that have pathological findings similar to the pancreas. Oral prednisolone is a very effective medicine and symptoms and clinical findings disappear soon after the start of steroid therapy. Focal type of AIP is sometimes very difficult to be differentiated from pancreato-biliary cancer that raises dispute over the use of steroids for the differential diagnosis.
自身免疫性胰腺炎（AIP）是一种被认为在自身免疫机制背景下发展起来的疾病。其特征在于影像学上的独特表现、各种自身抗体的出现以及血液中IgG和IgG4升高，病理上表现为淋巴细胞浆细胞性硬化性胰腺炎（LPSP）。它伴有各种胰腺外病变，这些病变具有与胰腺相似的病理表现。口服泼尼松龙是一种非常有效的药物，类固醇治疗开始后症状和临床体征很快消失。局灶型AIP有时很难与胰胆管癌相鉴别，这引发了关于使用类固醇进行鉴别诊断的争议。
